Most blind computer users use keyboard shortcuts to an extent almost incomprehensible to most sighted users who "point and click" for everything. Some prefer to put desktop shortcuts on the desktop, but they virtually never care where they are located, because it's first letter navigation via screen reader that gets them focus on the program they want to open. Even with desktop shortcuts, you can assign keyboard shortcuts to those, and some people do for their favorite programs. I can fire up NVDA (screen reader) with CTRL + ALT + N. Many others have virtually stopped using the desktop and get to almost anything via Windows search. I very much fall into that approach myself. Also, with the advent of the WinKey + Digit command in Win10/11 to direct fire up items you've placed in your taskbar (up to the first 10, starting with the digit 1 and ending with 0) many blind users have their "greatest hits" programs, e.g., File Explorer, Word, web browser of choice, email client, arranged in the taskbar in a specific order and use WinKey + Digit to fire them up.
When you can't point or click in conjunction with it, the way you use the computer is quite alien to most sighted persons. Even those of us who work with this population on a constant basis have to be very careful that our preference about how we do something is not presumed to be the client's preference as well.