Got a weird one!

GTP

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Location
Adelaide, Australia
Client has a laptop with a weird issue.
She has Skype for keeping in touch with relatives in UK.
2 days ago she turned on the laptop and went to invoke Skype. No desktop shortcut, no task bar shortcut, no start menu entry, no shortcut in All Programs.
So she calls me and I remote in.
No Program Files or Add/Remove Programs entry either?
Quick search for anything "Skype" gets nada!
Just for giggles I opened regedit and searched for anything "Skype" - nothing?!
It was completely and utterly gone!
Checked event logs, nothing. Ran LastActivityView thinking she may have uninstalled it. No.
So I download Skype and run the installer get no errors or problems Skype opens and she is happy.

Today she calls and says Skype is gone!
It was exactly the same thing, nothing left of Skype.
She told me she was chatting with Mum & Dad and briefly left them to get a cup of tea. She heard the familiar Skype closing sound and came back to see that Skype had closed and disappeared!
Utterly gone!

She brought the laptop to me and after checking Event Logs, (again, nothing) I reinstalled Skype
and left it on while I worked.
About 15 minutes later I heard the closing tone from Skype.
Sure enough it had disappeared again.
Ran Process Monitor looking for anything that may have been running that could stop Skype, but all other processes were "normal."
She has no third party software apart from MS Office 2013, Emsisoft Antimalware and Opera Browser, which, apart from the AM, were closed at the time.
I left Procmon running and reinstalled Skype from the downloaded .exe. Nothing odd, nothing that looks suspicious etc.15 minutes later its gone again!
Ran gsmartcontrol HDD ok, ran HardDisk Sentinel all ok, ran SFC all ok, ran chkdsk (seeing as how the drive was healthy) still the same.
Nothing much on google either?
Any help appreciated, TIA
 
Hmm. Run an analyzer tool to monitor the Skype process.

No RMM etc with a profile that blocks messaging platforms?

Create new user and test. If new user is ok profile has an issue or app in that profile.
 
No RMM etc with a profile that blocks messaging platforms?
Got an RMM but not blocking messaging platforms.
Thing is it's not being blocked - it's being obliterated, totally and utterly!
Created new user profile Skype shuts down within 15 minutes and disappears into the ether!
Virus and Malware Scans?
Run Emsisoft Rescue and Hitman Pro. Found nothing.
There's nothing on this computer so Client is happy for me to do N & P.
Heavy handed I know but where do you draw the line?
Spent way too much time on it already.
Thanks for suggestions guys!
 
Thanks for all the replies Guys, I've just finished the N & P. Very little on this computer, so easy Fabs backup, (although there was really nothing to back up) Install Windblows, apply updates, install Skype, Opera and Office. Done!
 
I had a weird one a few months ago, I don't remember the exact details but skype was causing serious problems with windows 10. I want to say it had something to do with the shortcut but im pretty certain it was the metro version. Which version of skype were you installing?
 
I had a weird one a few months ago, I don't remember the exact details but skype was causing serious problems with windows 10. I want to say it had something to do with the shortcut but im pretty certain it was the metro version. Which version of skype were you installing?
The Desktop one. 7.33.0.105
 
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