But clearly you, and the specific client you reference, have never encountered any of these in the ecosystem they've had active for a very long time.
Client(s)...plural..when referring to running into this situation.
Many things related to computers....can run in an unsupported setup OK for say, 90% of people. or say, 95% of people. But that 10, or 5, or 15...%...to me, that's not acceptable. Clients data is at risk! Regardless of it's just Outlook email, or...say, an accounting database. Quickbooks does not recommend, nor support, running their application across a VPN tunnel with the QBW file on the other end. Quickbooks is also, like Outlook, a very "chatty" (inefficient) database program. It sticks lots of fingers into the database. There's a chance of database corruption when running Quickbooks through a VPN tunnel in a typical fat client situation. Sure, it may work for 99% of users. But say..for 1% of users, the QBW file may corrupt. And that can get messy..and expensive, to repair.
I know, I know, we're talking about Outlook, not Quickbooks here.
But from my perspective, I'm supporting business clients. Not a stand alone home user. But since we're talking about keeping PST files across a network, onto a server, I'll go out on a limb and state we're talking about a business client here, not a home user. Although, well, you know my views on businesses and email...businesses should not be dealing with POP (nor IMAP) email here. But...sticking to topic of the thread...storing a PST on a mapped (or UNC path) network drive...
*Strains both the workstation (since Outlook itself will go into contention trying to work with a chatty database). Outlook can go into "not responding" more often.
*Strains network traffic...clogs up the network with heavier traffic, when the lanes on the network should be kept clear for other applications...so many PST files store on a server could really bog down larger more important LOB software.
*Strains server performance...there's a thing that greatly impacts server performance for a network..."TCQ"...Tagged Command Queue. The drives should be able to focus their energy on bigger things like LOB apps, and PST files...with their very chatty connection to Outlook, eat up TCQ cycles like a room full of PacMen gobbling up the dots.
*Antivirus software that should scan the mailbox....done from the client side...won't be able to properly read the PST. Antivirus software from client workstations should never..ever..scan mapped network drives anyways. This burdens the AV software of the server.
*Due to inefficiencies of the Outlook to PST connection when across a network, even when end users close Outlook at the end of the day...the file connection will often stay active to the PST on the server. Backup software on the server won't grab the PST properly (cleanly)...seen that many times.
Just because it will often work, doesn't mean it should be done.