I just got burned by Poweliks. The client complained that his laptop was running slowly. After running the usual tools and removing the malware I thought I was done. I rebooted thinking everything was OK.
Process Explorer showed the CPU functioning at 95-97%. I started IE and it opened slowly plus it couldn't find half the URL's I tried. Chrome was fine. No constant spawning of dllhost.exe files like the old version. I didn't know about conhost and notepad but do not recall seeing them. Double checked Proc Expl and still the CPU was at 95-97% idle.
I also couldn't download files with IE (Chrome fine) so that's when I ran ESET's Poweliks removal tool and it found and neutralized it.
Bitdefender offline, Roguekiller, the MBAX brothers and Combofix were all blind to it. I can't explain why this infection wasn't hogging system resources. Oh yeah, I almost forgot. Combofix took well over an hour to run. I've never seen that before. I originally thought it was hung at stage 5 (around 20 minutes on that single stage) but it eventually completed.