I'm all for a set it and forget it type of backup
I am looking into offering an online offsite backup for my clients(no software chosen yet). I do not think I will be using another service such as mozy or carbonite, since I don't get the warm fuzzies. Part of the service I will be offering is review of the logs to make sure that the backups are occuring, and that any problems are resolved in a timely manner.
You need to look at the time it takes to recover from a disaster, a few files, a directory, a significant amount of data, and finely a complete restore of an entire machine or server. The time a business will be down from a disastrer is critical in planning and buidgeting.
-- Tim