PC Perspective published a story that Intel’s SSD X25-M drive degrades as the drive is used due to file fragmentation. Intel could not replicate the problem yet.
The problem is not something an OS-based disk defragmenter can detect according to the article at Ars Technica.
The story that PC Perspective published include tips on how users could improve the drive’s performance.
“In our estimation, the synthetic workloads they use to stress the drive are not reflective of real world use,” Intel told CNET.
Source: Ars Technica

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The fragmentation seen in the intel X-25 is not file (OS) fragmentation, but internal fragmentation at the physical block level.
When it comes to filesystem problems, SSD random writes suffer more from free space fragmentation over time, rather than file fragmentation. Diskeeper say that free space consolidation helps to restore the performance. Rather than write long notes on the issue, let me post a few links.
http://forums.pcper.com/showthread.php?p=4351675
http://www.diskeeperblog.com/archives/2008/12/hyperfast_is_al.html
http://downloads.diskeeper.com/pdf/HyperFast.pdf